Sperm selection by fertile chip (zymot)
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What is the Fertile Chip (ZyMot)?
The Fertile Chip (ZyMot) is an innovative microfluidic device designed to select sperm with the highest potential for fertilisation and healthy embryo development. This chip simulates the natural conditions of the female vaginal tract, allowing sperm with better motility, morphology and less DNA fragmentation to advance through its microchannels, while those with deficient characteristics are left behind.
How does the Fertile Chip (ZyMot) work?
The sperm selection process using Fertile Chip (ZyMot) is carried out as follows:
- Semen sample preparation: A semen sample is obtained from the patient and centrifuged to separate the sperm from the seminal plasma.
- Sample insertion into the chip: The sperm sample is inserted into the Fertile Chip (ZyMot), where it flows through a series of microchannels designed to select the sperm with the best motility and morphology.
- Sperm selection: As sperm move through the microchannels, sperm with greater motility and normal structure overcome obstacles, while sperm with lower motility or abnormal morphology are left behind.
- Recovery of selected sperm: Sperm that have passed the on-chip selection process are recovered and used for assisted reproduction techniques such as in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).
What are the advantages of sperm selection by Fertile Chip (ZyMot)?
Sperm selection by Fertile Chip (ZyMot) offers several advantages:
- Higher fertilisation rate: By using sperm with better genetic quality and motility, the probability of successful fertilisation of the egg is increased.
- Improved embryo development: Embryos generated from spermatozoa selected with Fertile Chip (ZyMot) tend to show better development and a lower risk of chromosomal abnormalities.
- Increased chances of pregnancy: Assisted reproduction techniques using sperm selected with Fertile Chip (ZyMot) have higher gestational success rates.
- Reduced risk of miscarriage: By selecting sperm with less DNA fragmentation, the risk of miscarriage is reduced.
In which cases is sperm selection by Fertile Chip (ZyMot) recommended?
Sperm selection by Fertile Chip (ZyMot) is particularly recommended in the following cases:
- Couples having difficulty conceiving: If a couple is unable to achieve pregnancy after 12 months of unprotected sex, the Fertile Chip (ZyMot) can help identify and select sperm with higher fertility potential.
- History of recurrent miscarriage: If a couple has experienced recurrent miscarriages, the Fertile Chip (ZyMot) can help select sperm with less DNA fragmentation, which could reduce the risk of further miscarriages.
- Men with alterations in semen analysis (spermiogram): If the man's spermiogram shows alterations in sperm motility, morphology or sperm DNA fragmentation, the Fertile Chip (ZyMot) can help select the sperm with the best characteristics for fertilisation.
